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A Natural Solution For Reducing Pain and Inflammation
Use Mobility for natural pain relief for an aching back, sprained ankle or even that nagging headache. Pain-X will provide a natural reduction of inflammation.
Humans have been practicing various forms of pain management for thousands of years from the pain pipes of Native Americans to modern day pharmaceuticals. The question from educated consumers is at what risk am I willing to receive the benefit of pain relief.
Recent research1 published from the most reputable medical journal in England, The Lancet, has found ibuprofen (brand names: Advil, Motrin), to pose the same cardiovascular risk as Vioxx (Merck ), a drug that was removed from the market for the same such risks.
A New York Times article2 in 2012, discussed how Americans consume Ibuprofen with a false sense of security to the point that many athletes (70% of distance runners) consume the drug as a preventative measure for pain. A recent study proved that consuming ibuprofen before athletic events actually increased systemic inflammation by causing leaking of protein and enzymes from the intestines into the bloodstream.
Mobilty has a balanced and potent anti-inflammatory formulation that is made up of all natural ingredients. The dosage is higher than the pharmaceutical alternatives but the side effects are virtually non-existent.
The Unique Combination of Four Inflammation-Reducing Compounds
This very important herb has been shown to prevent mast cells from de-granulating during an allergic response which prevents the release of histamine. Quercetin also acts as an anti-inflammatory agent. It also protects the cartilage in your joints by inhibiting hyaluronidase which breaks down connective tissue.Therefore, this herb may protect joint cartilage, reduce inflammation and help in allergic symptoms!*
Tumeric Root Extract
This herb from the ginger family has been shown to inhibit both cyclooxygenase (COX) and lipoxygenase (LOX) which produce inflammatory prostaglandins and leukotrienes, inhibits platelet aggregation and neutrophil formation.Turmeric has also been found to have some cancer prevention qualities.*
It is used as an anti-inflammatory agent in both gross injury swellings (surgery, sprain) as well as micro-inflammation (allergic reactions).*
A proteolytic enzyme occurring in the unripe fruit of the papaya tree. Papain is used for pain and swelling (inflammation) as well as fluid retention following trauma.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Baigent, Colin, et al. "Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs." The Lancet 382.9894 (2013): 769-779.
Reynolds, Gretchen. “For Athletes, Risk From Ibuprofen Use.” New York Times. December 12, 2012.
As a dietary supplement, take two (2) or more capsules per day or as directed by your healthcare professional.
Do not use this product if you are pregnant or nursing. As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you anticipate surgery, take any medication (especially blood thinning medications, Corticosteroids, Cyclosporine, Digoxin, Fluoroguinolones and any liver medications) or are otherwise under medical supervision.
Formulated To Be Free of Allergens Derived From:
Wheat, soy, dairy, eggs, fish, crustacean shellfish, tree nuts, peanuts, artificial preservatives, sweeteners, color and flavors.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
References and Research Abstracts Supporting Pain-X
1. The Lancet, Volume 382, Issue 9894, Pages 769 - 779, 31 August 2013. doi:10.1016/S0140-6736(13)60900-9
2. Van Wuck, Kim et al. Medicine & Science in Sports & Exercise: Aggravation of Exercise-Induced Intestinal Injury by Ibuprofen in Athletes. December 2012 - Volume 44 - Issue 12 - p 2257–2262
3. Middleton E Jr. Effect of plant fl avonoids on immune and infl ammatory cell function. Adv Exp Med Biol 1998; 439: 175-182.
4. Blumenthal M, Busse WR, Goldberg A, et al. (eds). The Complete Commission E Monographs: Therapeutic Guide to Herbal Medicines. Boston, MA: Integrative Medicine Communications, 1998, 222.
5. Stavric B. Quercetin in our diet: from potent mutagen to probable anticarcinogen. Clin Biochem 1994;27:245-8.Heeba GH, Mahmoud ME, El Hanafy AA. Anti-inflammatory potential of curcumin and quercetin in rats: Role of oxidative stress, heme oxygenase-1 and TNF-α. Toxicol Ind Health. 2012 Sep 28.
6. Lee JH, Kim GH. Evaluation of antioxidant and inhibitory activities for different subclasses flavonoids on enzymes for rheumatoid arthritis. J Food Sci. 2010 Sep;75(7):H212-7. doi: 10.1111/j.1750-3841.2010.01755.x. PubMed PMID: 21535545.
7.Kanzaki N, Saito K, Maeda A, Kitagawa Y, Kiso Y, Watanabe K, Tomonaga A, Nagaoka I, Yamaguchi H. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study. J Sci Food Agric. 2012 Mar 15;92(4):862-9. doi: 10.1002/jsfa.4660. Epub 2011 Oct 3. PubMed PMID: 21969261.
8. Huang J, Zhu M, Tao Y, Wang S, Chen J, Sun W, Li S. Therapeutic properties of quercetin on monosodium urate crystal-induced inflammation in rat. J Pharm Pharmacol. 2012 Aug;64(8):1119-27. doi: 10.1111/j.2042-7158.2012.01504.x. Epub 2012 Mar 22. PubMed PMID: 22775215.
9. Abbey M, Noakes M, Belling GB, Nestel PJ. Partial replacement of saturated fatty acids with almonds or walnuts lowers total plasma cholesterol and low-density-lipoprotein cholesterol. Am J Clin Nutr 1994 May;59(5):995-9 1994. PMID:16240.
10. Aggarwal B. Paper presented at the U.S. Defense Department's 'Era of Hope' Breast Cancer Research Program meeting in Philadelphia, PA, October 5 2005,. reported in NUTRAingredients.com/Europe "Turmeric slows breast cancer spread in mice."
11. Ahsan H, Parveen N, Khan NU, Hadi SM. Pro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivatives demethoxycurcumin and bisdemethoxycurcumin. Chem Biol Interact 1999 Jul 1;121(2):161-75 1999. PMID:7690.
12. Arbiser JL, Klauber N, Rohan R, et al. Curcumin is an in vivo inhibitor of angiogenesis. Mol Med 1998 Jun;4(6):376-83 1998. PMID:7540.
13. Asai A, Nakagawa K, Miyazawa T. Antioxidative effects of turmeric, rosemary and capsicum extracts on membrane phospholipid peroxidation and liver lipid metabolism in mice. Biosci Biotechnol Biochem 1999 Dec;63(12):2118-22 1999. PMID:7550.
14. Balasubramanian K. Molecular Orbital Basis for Yellow Curry Spice Curcumin's Prevention of Alzheimer's Disease. J. Agric. Food Chem., 54 (10), 3512 -3520, 2006. 10.1021/jf0603533 S0021-8561(06)00353-0, Web Release Date: April 20, 2006. 2006.
15. Calabrese V, Butterfield DA, Stella AM. Nutritional antioxidants and the heme oxygenase pathway of stress tolerance: novel targets for neuroprotection in Alzheimer's disease. Ital J Biochem. 2003 Dec;52(4):177-81. 2003.
16. Calabrese V, et. al. Paper on curcumin's induction of hemeoxygenase-1. Presented at the annual conference of the American Physiological Society, held April 17-21, 2004, Washington, D.C. 2004.
17. Cruz-Correa M, Shoskes DA, Sanchez P, Zhao R, Hylind LM, Wexner SD, Giardiello FM. Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis. i>Clin Gastroenterol Hepatol. 2006 Aug;4(8):1035-8. Epub 2006 Jun 6. 2006. PMID:16757216.
18. Deshpande UR, Gadre SG, Raste AS, et al. Protective effect of turmeric (Curcuma longa L.) extract on carbon tetrachloride-induced liver damage in rats. Indian J Exp Biol 1998 Jun;36(6):573-7 1998. PMID:7740.
19. Dorai T, Cao YC, Dorai B, et al. Therapeutic potential of curcumin in human prostate cancer. III. Curcumin inhibits proliferation, induces apoptosis, and inhibits angiogenesis of LNCaP prostate cancer cells in vivo. Prostate 2001 Jun 1;47(4):293-303 2001. PMID:16280.
20. Egan ME, Pearson M, Weiner SA, Rajendran V, Rubin D, Glockner-Pagel J, Canny S, Du K, Lukacs GL, Caplan MJ. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science. 2004 Apr 23;304(5670):600-2. 2004. PMID:15105504.
21. Ensminger AH, Esminger M. K. J. e. al. Food for Health: A Nutrition Encyclopedia. Clovis, California: Pegus Press;1986 1986. PMID:15210
22. Fiala M, Lin J, Ringman J, Kermani-Arab V, Tsao G, Patel A, Lossinsky AS, Graves MC, Gustavson A, Sayre J, Sofroni E, Suarez T, Chiappelli F, Bernard G. Ineffective phagocytosis of amyloid-beta by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2005 Jun;7(3):221-32; discussion 255-62. 2005. PMID:16006665.
23. Fiala M, Liu PT, Espinosa-Jeffrey A, Rosenthal MJ, Bernard G, Ringman JM, Sayre J, Zhang L, Zaghi J, Dejbakhsh S, Chiang B, Hui J, Mahanian M, Baghaee A, Hong P, Cashman J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12849-54. 2007. PMID:17652175.
24. Fortin, Francois, Editorial Director. The Visual Foods Encyclopedia. Macmillan, New York 1996.
25. Grieve M. A Modern Herbal. Dover Publications, New York 1971.
26. Gururaj A, Kelakavadi M, Venkatesh D et al. Molecular mechanisms of anti-angiogenic effect of curcumin. Biochem Biophys Res Commun 2002 Oct 4;297(4):934 2002.
27. Hidaka H, Ishiko T, Furunashi T et al. Curcumin inhibits interleukin 8 production and enhances interleukin 8 receptor expression on the cell surface:impacgt on human pancrreatic carcinoma cell growth by autocrine regulation. Cancer 2002 Sep 15;96(6):1206-14 2002.
28. Kang BY, Chung SW, Chung W et al. Inhibition of interleukin-12 production in lipopolysaccharide-activated macrophage by curcumin. Eur J Pharmacol 1999 Nov;384(2-3):191-5 1999.
29. Kang BY, Song YJ, Kim KM et al. Curcumin inhibits Th1 cytokine profile in CD4+ T cells by suppressing interleukin-12 production in macrophages. Br J Pharmacol 1999 Sep;128(2):380-4 1999.
30. Khor TO, Keum YS, Lin W, Kim JH, Hu1 R, Shen G, Xu1 C, Gopalakrishnan A, Reddy B, Zheng X, Conney AH, Kong AN. Combined Inhibitory Effects of Curcumin and Phenethyl Isothiocyanate on the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice. Cancer Research. 2006 Jan; 66(2): 613-621. 2006. PMID:16423986.
31. Lim GP, Chu T, Yang F, et al. The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 2001 Nov 1;21(21):8370-7 2001. PMID:16240.
32. Nagabhushan M, Amonkar AJ, Bhide SV. In vitroantimutagenicity of curcumin against environmental mutagens. Food Chem Toxicol. 1987 Jul;25(7):545-7. 1987. PMID:3623345.
33. Nagabhushan M, Bhide SV. Curcumin as an inhibitor of cancer. J Am Coll Nutr. 1992 Apr;11(2):192-8. 1992. PMID:1578097.
34. Nagabhushan M, Nair UJ, Amonkar AJ, D'Souza AV, Bhide SV. Curcumins as inhibitors of nitrosation in vitro. Mutat Res. 1988 Nov;202(1):163-9. 1988. PMID:3054526.
35. Nagabhushan M. Research presented at the Children with Leukaemia Conference, www.leukaemia.org, September2004 2004.
36. Nakamura K, Yasunaga Y, Segawa T et al. Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines. Int J Oncol 2002 Oct;21(4):825-30 2002.
37. Natarajan C, Bright JJ. Peroxisome proliferator-activated receptor-gamma agonists inhibit experimental allergic encephalomyelitis by blocking IL-2 prodeuction, IL-12 signaling and Th1 differentiation. Genes Immun 2002 Apr;3(2):59-70 2002.
38. Olszewska M, Glowacki R, Wolbis M, Bald E. Quantitative determination of flavonoids in the flowers and leaves of Prunus spinosa L. Acta Pol Pharm 2001 May-2001 Jun 30;58(3):199-203 2001. PMID:16270.
39. Parfk SY, Kim DS. Discovery of natural products from Curcuma longa that protects cells from beta-amyloid insult: a drug discovery effort against Alzherimer's disease. J Nat Prod 2002 Sep;65(9):1227-31 2002.
40. Peschel D, Koerting R, Nass N. Curcumin induces changes in expression of genes involved in cholesterol homeostasis. J Nutr Biochem. 2007 Feb;18(2):113-9. Epub 2006 May 18. 2007. PMID:16713233.
41. Salh B, Assi K, Templeman V, Parhar K, Owen D, Gomez-Munoz A, Jacobson K. Curcumin attenuates DNB-induced murine colitis. Am J Physiol Gastrointest Liver Physiol. Jul;285(1):G235-43. Epub 2003 Mar 13 2003. PMID:12637253.
42. Shah BH, Nawaz Z, Pertani SA, et al. Inhibitory effect of curcumin, a food spice from turmeric, on platelet- activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signa. Biochem Pharmacol 1999 Oct 1;58(7):1167-72 1999. PMID:7670.
43. Shishodia S, Amin HM, Lai R, Aggarwal BB. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol. 2005 Sep 1;70(5):700-13. 2005. PMID:16023083.
44. Soni KB, Kuttan R. Effect of oral curcumin administration on serum peroxides and cholesterol levels in human volunteers. Indian J Physiol Pharmacol. 1992 Oct;36(4):273-5. 1992. PMID:1291482.
45.Tayyem RF, Heath DD, Al-Delaimy WK, Rock CL. Curcumin content of turmeric and curry powders. Nutr Cancer. 2006;55(2):126-31. 2006. PMID:17044766.
46. Wills RB, Scriven FM, Greenfield H. Nutrient composition of stone fruit (Prunus spp.) cultivars: apricot, cherry, nectarine, peach and plum. J Sci Food Agric 1983 Dec;34(12):1383-9 1983. PMID:16280.
47. Wood, Rebecca. The Whole Foods Encyclopedia. New York, NY: Prentice-Hall Press; 1988 1988. PMID:15220.
48. Wuthi-udomler M, Grisanapan W, Luanratana O, Caichompoo W. Antifungal activity of Curcuma longa grown in Thailand. Southeast Asian J Trop Med Public Health 2000;31 Suppl 1:178-82 2000. PMID:16270.
49. Yang F, Lim GP, Begum AN, Ubeda OJ, Simmons MR, Ambegaokar SS, Chen PP, Kayed R, Glabe CG, Frautschy SA, Cole GM. Curcumin inhibits formation of Abeta oligomers and fibrils and binds plaques and reduces amyloid in vivo. J Biol Chem. 2004 Dec 7; [Epub ahead of print] 2004. PMID:15590663.
50. Zhang L, Fiala M, Cashman J, Sayre J, Espinosa A, Mahanian M, Zaghi J, Badmaev V, Graves MC, Bernard G, Rosenthal M. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimers Dis. 2006 Sep;10(1):1-7. 2006. PMID:16988474.