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Drive Energy Levels and Improve Fat Burning Potential
Meta Trim is a scientifically-engineered and laboratory-tested formulation with weight loss ingredients supported by clinical research cited in over 10,000 scientific studies. Meta Trim is designed to provide quick changes in your body composition and to improve your post-workout recovery*.
Meta Trim is a proprietary blend of L-Carnitine, GABA, Medium Chain Triglycerides and Green Tea Leaf Extract.
The Signature Meta Trim Weight Loss Formulation:
This nutirent transports fat into the fat-burning furnace of your body (mitochondria) to maximize your weight loss efforts. During high energy output, the supply of L-carnitine becomes exhausted. When you add L-carnitine to your nutrient program, you body has the ability to use mobilize more fat for energy resulting in greater energy output and increased fat loss which translates to increased weight loss. Studies have shown that L-Carnitine will reduce overall fat mass and increase total muscle mass while reducing fatigue and improving cognitive function.1-2 It may also boost energy production by dumping the fumarate into the energy-producing machine of your body (The Krebs Cycle).
This herb is a natural appetite suppressant and energy enhancer derived from the succulent Asian cactus plant.3-4 It has been used by tribal Indians to suppress hunger, quench thirst, and enhance endurance. It has been shown to suppress appetite, and reduce waist circumference. Caralluma contain key phytochemicals including pregnane glycosides, flavone glycosides, megastigmane glycosides, bitter principles, saponins and various other flavonoids.5 The appetite suppressing action of Caralluma can be attributed to the pregnane glycosides which amplify signaling of the energy sensing function in the basal hypothalamus6 and acts directly on the adipose tissue by inhibiting adipocyte proliferation and differentation.7 Caralluma fimbriata may downregulate ghrelin synthesis in the stomach and neuropeptide-Y in the hypothalamus both having the effect of appetite suppression.8 Caralluma Fimbriata also has the ability to inhibit the proliferation of pre-adipocytes to reduce new fat cells.9
Medium Chain Triglycerides
The fat source has been shown to enhance thermogenesis (i.e., fat burning).10 since MCTs behave metabolically in some fashion similar to carbohydrates. They also promote the development of ketones to provide fuel for the brain in times of low carbohydrate intake.11
This tea contains high levels of antioxidant Epigallocatechin gallate (EGCG) and according to research can lower body fat and reduce cholesterol levels.12-13
The nutritional technology present in Meta Trim supports your weight loss efforts with a unique combination of appetite suppression, fat burning energy enhancement and post-workout recovery.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
1. Malaguarnera, M., Cammalleri, L., Gargante, M. P., Vacante, M., Colonna, V., & Motta, M. (2007). L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. The American journal of clinical nutrition, 86(6), 1738-1744.
2. Gwak, J. H., Lee, J. H., Lee, S. J., Park, H. W., Kim, Y., and Hyun, Y. J. The effect of L-carnitine and isoflavone supplementation on weight reduction and visceral fat accumulation in overweight women. Korean J.Nutrition 2007;40(7):630-638.
3*. Kota, Sunil K., et al. "Nutraceuticals in pathogenic obesity; striking the right balance between energy imbalance and inflammation." Journal of Medical Nutrition and Nutraceuticals 1.2 (2012): 63.
4.Kuriyan, Rebecca, et al. "Effect of Caralluma fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women." Appetite 48.3 (2007): 338-344.
5. Bader A, Braca A, De Tommasi N, Morelli I. Further constituents from Caralluma negevensis. Phytochemistry 2003;62:1277-81
6. MacLean DB, Luo LG. Increased ATP content/production in the hypothalamus may be a signal for energy-sensing of satiety: Studies of the anorectic mechanism of a plant steroidal glycoside. Brain Res 2004;1020:1-11
7. Cioffi G, Sanogo R, Vassallo A, Dal Piaz F, Autore G, Marzocco S, et al. Pregnane glycosides from Leptadenia pyrotechnica. J Nat Prod 2006;69:625-35.
8. Gardiner JV, Kong WM, Ward H, Murphy KG, Dhillo WS, Bloom SR. AAV mediated expression of antisense neuropeptide Y cRNA in the arcuate nucleus of rats results in decreased weight gain and food intake. Biochem Biophys Res Commun 2005;327:1088-93.
9*. Soundararajan, Kamalakkannan, et al. "Effect of Caralluma fimbriata extract on 3T3-L1 pre-adipocyte cell division." Food and Nutrition Sciences 2011 (2011).
10. Hill, James O., et al. "Thermogenesis in humans during overfeeding with medium-chain triglycerides." Metabolism 38.7 (1989): 641-648.
11. Yeh, Yu-Yan, and Paulus Zee. "Relation of ketosis to metabolic changes induced by acute medium-chain triglyceride feeding in rats." The Journal of nutrition 106.1 (1976): 58-67.
12. Klaus, S., et al. "Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation." International journal of obesity 29.6 (2005): 615-623.
13. Nagao, Tomonori, et al. "Ingestion of a tea rich in catechins leads to a reduction in body fat and malondialdehyde-modified LDL in men." The American journal of clinical nutrition 81.1 (2005): 122-129.
As a dietary supplement, take three (3) capsules one to two times a day or as directed by your health professional.
Do not use this product if you are pregnant, nursing or have kidney or liver disease. As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you are anticipate surgery, take any medication or are otherwise under medical supervision.
Formulated To Be Free of Allergens Derived From:
Wheat, dairy, eggs, fish, crustacean shellfish, tree nuts, peanuts, artificial preservatives, sweeteners, color and flavors.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
References and Research Abstracts Supporting Meta Trim
1. Natural Medicines. (n.d.). Retrieved May 16, 2016, from https:// naturalmedicines.therapeuticresearch.com/databases/food,-herbssupplements/professional.aspx?productid=1026
2. Malaguarnera, M., Cammalleri, L., Gargante, M. P., Vacante, M., Colonna, V., & Motta, M. (2007). L-Carnitine treatment reduces severity of physical and mental fatigue and increases cognitive functions in centenarians: a randomized and controlled clinical trial. The American journal of clinical nutrition, 86(6), 1738-1744.
3. Gwak, J. H., Lee, J. H., Lee, S. J., Park, H. W., Kim, Y., and Hyun, Y. J. The effect of L-carnitine and isofl avone supplementation on weight reduction and visceral fat accumulation in overweight women. Korean J.Nutrition 2007;40(7):630-638.
4. Azumano, I. and Yamanishi, T. A new use of pantothenic acid in metabolic syndrome treatment. Kagaku to Seibutsu 2008;46(6):400- 404.
5. Derosa, G., Maffi oli, P., Salvadeo, S. A., Ferrari, I., Gravina, A., Mereu, R., D’Angelo, A., Palumbo, I., Randazzo, S., and Cicero, A. F. Effects of combination of sibutramine and L-carnitine compared with sibutramine monotherapy on infl ammatory parameters in diabetic patients. Metabolism 2011;60(3):421-429.
6. Derosa, G., Maffi oli, P., Ferrari, I., D’Angelo, A., Fogari, E., Palumbo, I., Randazzo, S., and Cicero, A. F. Orlistat and L-carnitine compared to orlistat alone on insulin resistance in obese diabetic patients. Endocr.J 2010;57(9):777-786.
7. Derosa, G., Maffi oli, P., Ferrari, I., D’Angelo, A., Fogari, E., Palumbo, I., Randazzo, S., and Cicero, A. F. Comparison between orlistat plus l-carnitine and orlistat alone on infl ammation parameters in obese diabetic patients. Fundam.Clin Pharmacol 2011;25(5):642-651.
8. Plioplys AV, Plioplys S. Amantadine and L-carnitine treatment of Chronic Fatigue Syndrome. Neuropsychobiology 1997;35:16-23.
9. Borghi-Silva, A., Baldissera, V., Sampaio, L. M., Pires-DiLorenzo, V. A., Jamami, M., Demonte, A., Marchini, J. S., and Costa, D. L-carnitine as an ergogenic aid for patients with chronic obstructive pulmonary disease submitted to whole-body and respiratory muscle training programs. Braz.J Med.Biol.Res. 2006;39(4):465-474.
10. Giamberardino, M. A., Dragani, L., Valente, R., di Lisa, F., Saggini, R., and Vecchiet, L. Effects of prolonged L-carnitine administration on delayed muscle pain and CK release after eccentric effort. Int J Sports Med 1996;17(5):320-324.
11. Karahan, M., Cokseym, B., and Arts, S. The effect of L-carnitine supplementation on 1500 m running performance. Ovidius University Annals, Physical Education and Sport/Science, Movement and Health Series 2010;10(Suppl 2):504-507.
12. Kaviani, M., Nourshahi, M., and Shokoohi, F. The effects of acute L-carnitine administration on ventilatory breakpoint and exercise performance during incremental exercise. J.Mazandaran Univ.Med. Sci. 2009;19(73):43-50.
13. Wall BT1, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL. Chronic oral ingestion of L-carnitine and carbohydrate increases muscle carnitine content and alters muscle fuel metabolism during exercise in humans. J Physiol. 2011 Feb 15;589(Pt 4):963-73.
14. Baba, N., Bracco, E.F., Seylar, J., Hashim, S.A. Enhanced thermogenesis and diminished deposition of fat in response to overfeeding with diets containing medium chain triglycerides. J Am Soc Clin Nutrition, 1981, 34: 624.
15. Kuriyana, Rebecca, et al. Effect of Caralluma Fimbriata extract on appetite, food intake and anthropometry in adult Indian men and women. Appetite. Volume 48, Issue 3, May 2007, Pages 338–344
16. F. Thielecke, G, et al. Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers. European Journal and Clinical Nutrition.F. Thielecke, G, et al. Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers. European Journal and Clinical Nutrition.(2010) 64,704-713.
17. Stoner GD, Mukhtar H. Polyphenols as cancer chemopreventive agents. J Cell Bioch 1995;22:169-80.
18. You SQ. Study on feasibility of Chinese green tea polyphenols (CTP) for preventing dental caries. Chin J Stom1993;28(4):197-9.
19. Hamilton-Miller JM. Antimicrobial properties of tea (Camellia sinensis L.). Antimicrob Agents Chemother 1995;39:2375-7.
20. Georg, M. G., Kristensen, M., Belza, A., Knudsen, J. C., & Astrup, A. (2012). Acute Effect of Alginate-Based Preload on Satiety Feelings, Energy Intake, and Gastric Emptying Rate in Healthy Subjects. Obesity, 20(9), 1851-1858.